|
KMID : 0857020060210010328
|
|
Kosin Medical Journal
2006 Volume.21 No. 1 p.328 ~ p.332
|
|
|
Non-Metaplastic Dysplasia as precursor lesion of Diffuse type stomach carcinoma
|
|
Chang Hee-Kyung
Choi Jong-Soon
|
|
|
Abstract
|
|
|
Background : This study was performed to investigate the relationship of types of dysplasia and histologic types in 141 cases of surgical specimens of early gastric cancer.
Material and methods : Fromalin-fixed and paraffin-embedded gastric mucosa and cancer tissue from 141 patients with gastric cnacer underwent gastrectomy were studided with classification of gasric cancer by Lauren and dysplasia.
Results : The histologic types by Lauren1) were: diffuse type 59 cases (41.84%); intermediate type 41 cases (29.08%); and intestinal type 41 cases (29.08%). The types of gastric dysplasia in gastric mucosa adjacent to the tumor were classified into nonmetaplastic dysplasia 98 cases (69.50%) and metaplastic dysplasia 97 cases (68.8%). Simultaneous presentation of both dysplasias was 55 cases (39.00%). The frequency of nonmetaplastic dysplasia in diffuse and intermediate type carcinoma was significantly higher than in intestinal type carcinoma (p<0.05), and the frequency of metaplastic dysplasia in intestinal type carcinoma was significantly higher than that of diffuse and intermediate carcinoma (p<0.05). In cases of metaplastic dysplasia, age and frequency and severity showed positive correlation (p<0.05).
Conclusions : These results suggest that types of dysplasias may be related to two different pathways in human stomach carcinogenesis. And we propose a hypothesis that nonmetaplastic dysplasia and diffuse type adenocarcinoma sequence may be possible in the development of diffuse type of stomach cancer.
|
|
|
KEYWORD
|
|
|
Sastric Cancer, Dysplasia, Non-metaplastic, Lauren classification
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|